靶向型DSPE-PEG-cRGD纳米颗粒增强的眼底光声与OCT多模态成像-UDP糖丨MOF丨金属有机框架丨聚集诱导发光丨荧光标记推荐西安齐岳生物

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靶向型DSPE-PEG-cRGD纳米颗粒增强的眼底光声与OCT多模态成像

发布时间：2025-06-23 作者：kx 分享到：

靶向型DSPE-PEG-cRGD纳米颗粒增强的眼底光声与OCT多模态成像

链接：https://openurl.ebsco.com/EPDB%3Agcd%3A14%3A1971790/detailv2?sid=ebsco%3Aplink%3Acrawler&id=ebsco%3Adoi%3A10.1515%2Fnanoph-2023-0872&link_origin=none

作者：Du, Fengxian; Niu, Chen; Zeng, Silue; Chen, Jingqin; Liu, Chengbo; Dai, Cuixia

摘要：In this paper, we design a multimodal visible/near-infrared photoacoustic microscopy and optical coherence tomography (VIS/NIR-PAM-OCT) system for imaging both retina and retinal pigment epithelium (RPE)/choroid complex layer. F127 and DSPE-PEG-cRGD encapsulated IR-1048 nanoparticles (FINPs) exhibiting absorption peak up to 1,064 nm were utilized as contrast agents to enhance NIR-PAM for in vivo imaging of fundus tissues. The fundus structure and vessels are clearly visualized by the multimodal imaging, and their parameters were quantitatively analyzed. NIR-PAM and OCT imaging of fundus were time-serially monitored over 60 min following the intravenous injection of FINPs into rats. The results indicated a 134 % increase in image signals in PAM at 1 min, along with an 8.23 % intensity enhancement in OCT. Moreover, laser-induced choroidal neovascularization (CNV) was specifically detected and accurately quantified using VIS/NIR-PAM-OCT. Lastly, FINPs demonstrated excellent biocompatibility in hematology analysis and pathology testing.

译文：

在这篇论文中，我们设计了一种多模式可见/近红外光声显微镜和光学相干断层扫描（VIS/NIR-PAM-OCT）系统，用于对视网膜和视网膜色素上皮（RPE）/脉络膜复合层进行成像。F127和DSPE-PEG-cRGD包封的IR-1048纳米颗粒（FINP）具有高达1064nm的吸收峰，被用作造影剂，以增强眼底组织的NIR-PAM体内成像。多模态成像清晰地显示了眼底结构和血管，并对其参数进行了定量分析。在大鼠静脉注射FINP后60分钟内，对眼底的NIR-PAM和OCT成像进行时间序列监测。结果表明，1分钟后PAM的图像信号增加了134%，OCT的强度增强了8.23%。此外，使用VIS/NIR-PAM-OCT专门检测并准确定量了激光诱导的脉络膜新生血管（CNV）。最后，FINP在血液学分析和病理学测试中表现出*的生物相容性。

DOI：10.1515/nanoph-2023-0872

靶向型DSPE-PEG-cRGD纳米颗粒增强的眼底光声与OCT多模态成像