文献：

Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer

文献链接：

https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.575365/full

作者：

Jun Shao&#x;Jun Shao1†Xiaoming Zheng&#x;Xiaoming Zheng1†Longbao FengLongbao Feng2Tianyun LanTianyun Lan3Dongbing DingDongbing Ding1Zikai CaiZikai Cai1Xudong ZhuXudong Zhu1Rongpu LiangRongpu Liang1Bo Wei*Bo Wei1*

As shown in Scheme 1, first, DSPE-PEG-RGD was obtained based on the Michael addition reaction between RGD peptide and DSPE-PEG-Mal. Second, the NIR agent ICG was encapsulated by the DSPE-PEG-RGD matrix via the self-assembly method. DSPE-PEG-Mal is an amphiphilic polymer. PEG serves as a hydrophilic unit to form the shell while DSPE is a hydrophobic unit to form the hydrophobic cavity with ICG in the core. The synthesis and Characteristics of DSPE-PEG-RGD@ICG were analyzed, including 1H NMR spectroscopy, transmission electron microscope (TEM), and so on. Then, the cellular uptake and biocompatibility were assessed. In addition, by using an optical imaging system, we observed the biodistribution and improved accumulation of DSPE-PEG-RGD@ICG in the tumor. The results of this study may provide a promising nanocarrier to realize the future clinical application of optical molecular imaging in early diagnosis and accurate resection of GC.

首先，基于RGD肽和DSPE-PEG-Mal之间的Michael加成反应获得DSPE-PEG-RGD。其次，通过自组装方法将近红外试剂ICG包封在DSPE-PEG-R GD基质中。

DSPE-PEG-Mal是一种两亲性聚合物。PEG作为亲水单元形成外壳，而DSPE作为疏水单元形成疏水腔，ICG位于核心。合成及其特性DSPE-PEG-RGD@ICG通过1H NMR光谱、透射电子显微镜（TEM）等进行分析，然后评估细胞摄取和生物相容性。

此外，通过使用光学成像系统，我们观察了DSPE-PEG-RGD@ICG在肿瘤中。本研究的结果可能为实现光学分子成像在GC早期诊断和准确切除中的未来临床应用提供有前景的纳米载体。

相关推荐产品：

TH-PEG-DSPE

R6H4-PEG-DSPE

MPG-PEG-DSPE

GE11-PEG-DSPE

PTP-PEG-DSPE

SP94-PEG-DSPE

T7(HAIYPRH)-PEG-DSPE

Octreotide-PEG-DSPE

YIGSR-PEG-DSPE

APRPG-PEG-DSPE

NGR-PEG-DSPE

以上文章内容来源各类期刊或文献，如有侵权请联系我们删除！