文献：两亲性聚乙二醇接枝共聚物的离散库：合成、组装和生物活性

链接：https://pubs.acs.org/doi/abs/10.1021/jacs.2c07859

作者：陈俊峰奥恩·里兹维约瑟夫·P·帕特森克雷格·J·霍克*

节选：

聚乙二醇 (PEG) 是一种重要且广泛用于生物和制药领域的聚合物，其作用是*大限度地减少非特异性结合，同时改善*/成像剂的血液循环。然而，市售 PEG 样品具有多分散性，这阻碍了对其链长依赖性特性的详细研究，并可能在药物应用中增强*体反应。本文，我们报告了一种实用且可扩展的方法，用于制备具有支链非线性结构的离散 PEG 类似物库。这些脂质-PEG 衍生物具有单分散主链，其侧链包含离散数量的乙二醇单元（3 或 4 个）和*的可功能化链端。值得注意的是，与市售多分散线性体系（例如 DMG-PEG2000）相比，这种支链非线性结构已被证明能够实现高效的纳米颗粒组装，同时降低* PEG *体识别率。通过实现大量接枝共聚物库的可扩展合成，可以理解其基本的自组装特性，并证明其与 PEG 单元总数、链端性质和主链总长度直接相关。这些结果说明了离散大分子与传统分散材料相比的优势。

Abstract

Poly(ethylene glycol) (PEG) is an important and widely used polymer in biological and pharmaceutical applications for minimizing nonspecific binding while improving blood circulation for therapeutic/imaging agents. However, commercial PEG samples are polydisperse, which hampers detailed studies on chain length-dependent properties and potentially increases antibody responses in pharmaceutical applications. Here, we report a practical and scalable method to prepare libraries of discrete PEG analogues with a branched, nonlinear structure. These lipid-PEG derivatives have a monodisperse backbone with side chains containing a discrete number of ethylene glycol units (3 or 4) and unique functionalizable chain ends. Significantly, the branched, nonlinear structure is shown to allow for efficient nanoparticle assembly while reducing anti-PEG antibody recognition when compared to commercial polydisperse linear systems, such as DMG-PEG2000. By enabling the scalable synthesis of a broad library of graft copolymers, fundamental self-assembly properties can be understood and shown to directly correlate with the total number of PEG units, nature of the chain ends, and overall backbone length. These results illustrate the advantages of discrete macromolecules when compared to traditional disperse materials.

西安齐岳生物提供相关产品：

DSPE-PEG-Angiopep-2 (二硬脂酰基磷脂酰乙醇胺-聚乙二醇-整合素靶向环肽)

DSPE-PEG-CLS

DSPE-PEG2K-R8

DSPE-PEG-TRITC

DSPE-PEG-Biotin

Peptides PEG PCL

DSPE-PEG-HZ

DPPE-PEG-RGD

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