文献：AIE-Featured Redox-Sensitive Micelles for Bioimaging and Efficient Anticancer Drug Delivery

作者：by Wei Zhao 1,†,Zixue Li 1,†,Na Liang 2,*,Jiyang Liu 1,Pengfei Yan 1 andShaoping Sun

 文献链接：https://www.mdpi.com/1422-0067/23/18/10801

The HO-TPE-OH was prepared as previously reported [38]. At first, HEBP was synthesized. HBP (1.9 g), K2CO3 (2.76 g), and 2-bromoethanol (1.25 g) were mixed, and the reaction was proceeded for 24 h at 110 °C. The resultant was extracted with dichloromethane and then purified by silica gel column chromatography to provide HEBP as a white crystalline solid.

Then HEBP (484 mg), zinc powder (160 mg), THF (3 mL), and TiCl4 (0.5 mL) were mixed under nitrogen atmosphere. The reaction was carried out under stirring for 12 h and then quenched by the addition of hydrochloric acid. The resultant was extracted with ethyl acetate and dried over anhydrous Na2SO4. The crude product was purified by silica gel column chromatography. HO-TPE-OH was isolated as a yellow solid.

HO-TPE-OH的合成

HO-TPE-OH的制备方法如前所述[38]。首先，合成了HEBP。将HBP（1.9 g）、K2CO3（2.76 g）和2-溴乙醇（1.25 g）混合，在110°C下反应24小时。所得物用二氯甲烷萃取，然后通过硅胶柱色谱纯化，得到白色结晶固体HEBP。

然后在氮气气氛下混合HEBP（484mg）、锌粉（160mg）、THF（3mL）和TiCl4（0.5mL）。反应在搅拌下进行12小时，然后通过加入盐酸淬灭。所得物用乙酸乙酯萃取，用无水Na2SO4干燥。粗产物通过硅胶柱色谱纯化。HO-TPE-OH分离为黄色固体。

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