文献：Surface Functionalized Gold Nanorods: Tracking and Observing Live Cell via Three Optical Signals

 作者：Qiu, Xiaozhong; Wang, Yaling; Cui, Yanyan; Sun, Zhipeng; Liu, Ru; Huang, Wenhua; Zhao, Feng; Zu, Yan; Yuan, Hui; Chang, Xueling; Gao, and Xueyun

文献链接：https://www.ingentaconnect.com/contentone/asp/jnn/2012/00000012/00000009/art00004

Surface functionalized gold nanorods (GNRs) with three optical signals and the ability to track and observe live cells was investigated. The Cetyltrimethyl Ammonium Bromide (CTAB) was used as the shape-directing agent to develop GNRs with uniform size and aspect ratio. The as-synthesized GNRs can strongly enhance the Raman signal of the attached MGITC on the GNRs. Polyethylene glycol (SH-PEG-COOH) and SH-PEG-FITC were attached with GNRs through ligand exchange with CTAB. They can stabilize the GNRs, reduce the cytotoxicity and provide fluorescence signal. A cell-penetrating peptide was covalently conjugated with SH-PEG-COOH to assist the GNRs to enter living cell. After cultured with the MCF-7 cells, the surfaced functionalized Au nanorods can enter the MCF-7 cells and be tracking with enhanced MGITC Raman signal, FITC fluorescence, and Rayleigh scatter signal.

研究了具有三种光信号的表面功能化金纳米棒（GNR）以及跟踪和观察活细胞的能力。使用十六烷基三甲基溴化铵（CTAB）作为形状导向剂，开发出尺寸和纵横比均匀的GNR。

合成的GNR可以强烈增强GNR上附着的MGITC的拉曼信号。聚乙二醇（SH-PEG-COOH）和SH-PEG-FITC通过与CTAB的配体交换与GNR连接。

它们可以稳定GNR，降低细胞毒性并提供荧光信号。细胞穿透肽与SH-PEG-COOH共价结合，以帮助GNR进入活细胞。

与MCF-7细胞一起培养后，表面官能化的Au纳米棒可以进入MCF-7细胞，并用增强的MGITC拉曼信号、FITC荧光和瑞利散射信号进行跟踪。

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