文献：基于Diels-Alder反应的可注射缓释水凝胶的制备及其理化性质

作者：李聪聪，陈道远，李明慧，张文，张蓬，孙考祥

文献链接：https://xueshu.baidu.com/usercenter/paper/show?paperid=1m690r508t010vb0x72402x0xn322969&site=xueshu_se

摘要：

The aim of this study was to prepare an injectable sustained release hydrogel through drug polymer coupling model and Diels Alder click reaction

Puerarin hyaluronic acid coupling compound (PUE-HA) was prepared by connecting puerarin and hyaluronic acid through amide bond. PUE-HA and 4-arm maleimide polyethylene glycol (4-arm PEG-MAL) were crosslinked through Diels Alder click reaction to prepare injectable sustained-release hydrogel (PUE-HA-PEG) Compared with 1Furan/1MI and 1Furan/2MI hydrogels, the gelation time of 1Furan/4MI hydrogels can be shortened to 1 min. With the increase of MI ratio, the hydrogels have lower degradation rate (21 day degradation rate is less than 60%), better mechanical properties, and more obvious drug release effect

The experimental results show that the ratio of Furan/MI has a significant impact on the physical and chemical properties of injectable sustained-release hydrogels

本研究旨在通过药物-聚合物偶联物模型和Diels-Alder点击反应制备一种可注射缓释水凝胶.

将葛根素与透明质酸通过酰胺键连接得到葛根素-透明质酸偶联物(PUE-HA),将PUE-HA和四臂马来酰亚胺聚乙二醇(4-arm-PEG-MAL)通过Diels-Alder点击反应交联制备了可注射缓释水凝胶(PUE-HA-PEG),并考察了三种不同呋喃(Furan)与马来酰亚胺基(MI)比例对所得水凝胶的胶凝时间,形貌,溶胀度,降解度,葛根素体外释放,水凝胶力学性能以及水凝胶生物相容性等理化性质的影响.与1Furan/1MI和1Furan/2MI水凝胶相比,1Furan/4MI的水凝胶胶凝时间可缩短至1 min.随着MI比例的增加,水凝胶具有更低的降解速率(21 d降解率低于60%),更好的力学性能,缓释释药作用更加明显.

实验结果表明,Furan/MI的比例对可注射缓释水凝胶的理化性质具有重大影响.

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