文献：顺铂负载EGF修饰mPEG-PLGA-PLL纳米粒子对小鼠SKOV3癌的毒性及*作用

链接：https://www.sciencedirect.com/science/article/abs/pii/S0142961212014135

作者：王云飞 a b 1，刘培峰 c 1，邱丽华 a b，孙英  ，朱明杰  ，顾丽英 a b，温迪   ，段 友容c

节选：

构建具有低毒性和特异性*靶向性的纳米粒子具有挑战性，需要仔细设计纳米粒子的组成、尺寸和物理化学性质。这里制备了表皮生长因子（EGF）修饰的甲氧基聚乙二醇-聚乳酸-乙醇酸-聚赖氨酸（mPEG-PLGA-PLL）包裹的顺铂（CDDP）纳米粒子（CDDP-NPs-EGF）以解决 CDDP 的毒性并提高*效率。CDDP-NPs-EGF 的显着特点是在体外增加细胞毒性，这归因于有效的细胞周期停滞和高细胞凋亡。在体内，CDDP-NPs-EGF 改变了药物分布，降低了CDDP 的肾毒性，显着提高了*效率，而没有引起明显的系统毒性，验证了其在降低药物毒性和增强小鼠SKOV3 癌**效率方面的关键作用。

Construction on the nanoparticles with lower toxicity and specific tumor targeting properties is challenging and requires careful design of composition, size, physicochemical properties tailored for the nanoparticles. Here the epidermal growth factor (EGF) modified methoxy polyethylene glycol-polylactic-co-glycolic acid-polylysine (mPEG-PLGA-PLL) encapsulated cisplatin (CDDP) nanoparticles (CDDP-NPs-EGF) was prepared to for solving the toxicity of CDDP and improving therapeutic efficiency. The remarkable features of CDDP-NPs-EGF are increasing cytotoxicity that attribute to effective cell cycle arrest and high cell apoptosis in vitro. In vivo, the CDDP-NPs-EGF change drug distribution, decrease the nephrotoxicity of CDDP and improve significantly therapeutic efficiency without inducing obvious system toxicity, verifying its key role of the CDDP-NPs-EGF in lowering drug toxicity and enhancing the antitumor efficiency for SKOV3 cancer in mice.

西安齐岳生物提供相关产品：

PLL(20)-g[3.5]-PEG(2)，多聚赖氨酸支链共聚聚乙二醇，Poly-L-lysine2500-g[3.5]-PEG88

PLL(20)-g[5]-PEG(2)

PLL(30)-g[3.5]-PEG(2)

PLL(30)-g[5]-PEG(2)

PLL(20)-g[3.5]-PEG(4)

PLL(20)-g[5]-PEG(4)

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