常用名：α1A-AR Degrader 9c 

描述：

α1A-AR Degrader 9c (化合物 9c) 是一种强效的、选择性的、可逆的 α1A-AR (肾上腺素能受体) PROTAC 降解物，其 DC50 为 2.86 μM。α1A-AR Degrader 9c 诱导的 α1A-AR 降解可归因于蛋白酶体降解。α1A-AR Degrader 9c 对 PC-3 细胞的增殖具有抑制作用，其 IC50 为 6.12 μM。

生物活性

α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].

IC50 & Target α1A-adrenergic receptor

2.86 μM (DC50)

体内研究

(In Vivo)

α1A-AR Degrader 9c (compound 9c) (50 mg/kg, IP, once daily for 15 days) causes a significant suppression of tumor growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量 829.82

Formula C38H43N11O11

CAS 号 2863635-02-1

运输条件 Room temperature in continental US; may vary elsewhere.

储存方式 Please store the product under the recommended conditions in the Certificate of Analysis.

产地：西安

用途：科研

厂家：西安齐岳生物科技有限公司

温馨提示：仅用于科研！

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