产品描述:
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
体外活性 DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer.
体内活性 As determined by loss of body weight and death of treated mice,DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity[2].
别名 N,N''-Carbonylbis[L-glutamic acid], (2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid
分子量 320.25
分子式 C11H16N2O9
CAS No. 302941-52-2
存储
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度
DMSO: 280 mg/mL (874.32 mM)
H2O: 140 mg/mL (437.16 mM)
PROteolysis TArgeting Chimeras (PROTACs) 通过将靶蛋白和 E3 连接酶结合起来,从而“劫持”细胞的泛素-蛋白酶体系统(UPS)来实现蛋白质的降解。由于 PROTACs 只需具有高选择性地结合其靶标(而不是抑制靶蛋白的酶活性),目前有许多努力将先前无效的抑制剂分子改造为 PROTACs,用作下一代药物。
产地:西安
用途:科研!
厂家:西安齐岳生物科技有限公司
温馨提示:仅用于科研,不能用于人体实验!
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