DSPE-PEG-PEI非功能化单壁碳纳米管用于SiRNA递送的应用-UDP糖丨MOF丨金属有机框架丨聚集诱导发光丨荧光标记推荐西安齐岳生物

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DSPE-PEG-PEI非功能化单壁碳纳米管用于SiRNA递送的应用

发布时间：2025-06-19 作者：zyl 分享到：

文献：Non-Covalently Functionalized of Single-Walled Carbon Nanotubes by DSPE-PEG-PEI for SiRNA Delivery

文献链接：https://xueshu.baidu.com/usercenter/paper/show?paperid=38060aa6b16da1fd532d375e0351a6b6&site=xueshu_se

作者：KS Siu，Y Zhang，X Zheng，J Koropatnick，WP Min

摘要：

The expression of a gene can be specifically downregulated by small interfering RNA (SiRNA). Modified carbon nanotubes (CNT) can be used to protect SiRNA and facilitate its entry into cells. Regardless of that, simple and efficient functionalization of CNT is lacking. Effective SiRNA delivery can be carried out using non-covalently functionalized CNT, where non-covalent (versus covalent) functionalization is simpler and more expeditious. Non-covalently functionalized single walled carbon nanotubes (SWCNT) that include a lipopolymer are described here. Polyethylenimine (PEI) conjugated to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG) was generated and the products used to disperse CNT to form DSPE-PEG-PEI/CNT (DGI/C), an agent capable of facilitating SiRNA delivery to cells in vitro and organs and cells in vivo.

DSPE-PEG-PEI

基因的表达可以被小干扰RNA（SiRNA）特异性下调。改性碳纳米管（CNT）可用于保护SiRNA并促进其进入细胞。尽管如此，仍缺乏简单有效的CNT功能化。有效的SiRNA递送可以使用非共价官能化的CNT进行，其中非共价（与共价相比）官能化更简单、更快捷。这里描述了包括脂聚合物的非共价官能化单壁碳纳米管（SWCNT）。生成了与1,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺-N-[氨基（聚乙二醇）-2000]（DSPE-PEG）偶联的聚乙烯亚胺（PEI），并将产物用于分散CNT以形成DSPE-PEG-PEI/CNT（DGI/C），这是一种能够促进SiRNA在体外递送到细胞和体内器官和细胞的试剂。