文献：Self-targeted salinomycin-loaded DSPE-PEG-methotrexate Nanomicelles for Targeting Both Head and Neck Squamous Cell Carcinoma Cancer Cells and Cancer Stem Cells

文献链接：https://www.tandfonline.com/doi/abs/10.2217/nnm-2016-0382

作者：Minhui Zhu,Shicai Chen,Libo Hua,Caiyun Zhang,Mengjie Chen,Donghui Chen,Yinmei Dong,Yingying Zhang,Meng Li,Xianmin Song,Huaiwen Chen &Hongliang Zheng 

摘要：

To target both head and neck squamous cell carcinoma (HNSCC) cells and cancer stem cells (CSCs) by salinomycin-loaded DSPE-PEG-MTX (synthesized using DSPE-PEG2000-NH2 and methotrexate) nanomicelles (M-SAL-MTX). Materials & methods: The characterization, antitumor activity and mechanism of M-SAL-MTX were evaluated. Results & conclusion: M-SAL-MTX showed enhanced inhibitory effect toward both HNSCC CSCs and non-CSCs compared with a single treatment of methotrexate and salinomycin. In nude mice-bearing HNSCC xenografts, M-SAL-MTX suppressed tumor growth more effectively than other controls including combination of methotrexate and salinomycin. Therefore, M-SAL-MTX may provide a strategy for treating HNSCC by targeting both HNSCC CSCs and HNSCC cells.

通过盐霉素负载的DSPE-PEG-MTX（使用DSPE-PEG 2000-NH2和甲氨蝶呤合成）纳米胶束（M-SAL-MTX）靶向头颈部鳞状细胞癌（HNSCC）细胞和癌症干细胞（CSCs）。

材料与方法：对M-SAL-MTX的特性、*肿瘤活性及其作用机制进行了评估。

结果与结论：与甲氨蝶呤和盐霉素单一治疗相比，M-SAL-MTX对HNSCC CSCs和非CSCs的抑制作用增强。在携带HNSCC异种移植物的裸鼠中，M-SAL-MTX比其他对照组（包括甲氨蝶呤和盐霉素的组合）更有效地抑制肿瘤生长。因此，M-SAL-MTX可以通过靶向HNSCC CSC和HNSCC细胞来提供治疗HNSCC的策略。

相关推荐：

DSPE-PEG-PLA

DSPE-PEG-PLGA

DSPE-PEG-Progestrone

DSPE-PEG-RGD

DSPE-PEG-SC

DSPE-PEG-SCM

DSPE-PEG-SG

DSPE-PEG-SH

DSPE-PEG-Silane

DSPE-PEG-SP2-AA

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