基于SH-PEG-DOX的多功能纳米复合材料构建及其pH响应药物释放性能研究-UDP糖丨MOF丨金属有机框架丨聚集诱导发光丨荧光标记推荐西安齐岳生物

A multifunctional cancer therapy nanocomposite was proposed and synthesized by linking the pH-responsive SH-PEG-DOX prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles (UCNPs). In the structure of the SH-PEG-DOX prodrug, a hydrazone bond was utilized for subsequent pH-responsive drug release in the intracellular acidic microenvironment of cancer cells. This innovative assembly method is facile and mild, and can be used to obtain nanocomposites of UCNPs and gold, which show excellent photostability and biocompatibility. The final UCNPs@Au-DOX nanocomposites offer efficient treatment effects in vitro under irradiation with an 808 nm laser due to the synergistic effect of chemotherapy and photothermal therapy. In addition, the UCNPs@Au-DOX nanocomposites show excellent intracellular locating ability via upconversion luminescence (UCL) imaging with Er3+ ions and magnetic resonance imaging (MRI) with Gd3+ ions, indicating that they have potential as a visual tracking agent in cancer treatment. Therefore, the presented bioimaging-guided multifunctional synergistic therapy nanocomposites are promising tools for imaging-guided cancer therapy.

SH-PEG-DOX

提出并合成了一种多功能*症纳米复合材料，将pH响应性SH-PEG-DOX前药连接到原位生长在上转化纳米颗粒（UCNP）表面的金纳米晶体上。在SH-PEG-DOX前药的结构中，利用腙键在*症细胞的细胞内酸性微环境中进行随后的pH响应性药物释放。这种创新的组装方法简单温和，可用于获得UCNP和金的纳米复合材料，显示出优异的光稳定性和生物相容性。决赛UCNPs@Au-DOX由于化疗和光热治疗的协同作用，纳米复合材料在808nm激光照射下在体外提供了有效的治疗效果。此外UCNPs@Au-DOX纳米复合材料通过Er3+离子的上转换发光（UCL）成像和Gd3+离子的磁共振成像（MRI）显示出优异的细胞内定位能力，表明它们在*症治疗中具有潜在的视觉跟踪剂。因此，所提出的生物成像导向多功能协同治疗纳米复合材料是成像导向*症治疗的有前途的工具。