文献：可生物降解阳离子三嵌段共聚物mPEG-PCL-PLL的合成及其用于siRNA递送

链接：https://www.sciencedirect.com/science/article/abs/pii/S016836591100681X

作者：若谷 奇 1 2，美丽 湖 1号，乐山 燕 1 2，陈学思 1，黄玉斌 1，夏 滨井 1

节选：

通过对mPEG-PCL末端羟基进行叠氮化，再对叠氮基进行氢化，合成了端氨基甲氧基聚乙二醇-b-聚己内酯（mPEG-PCL-NH 2 ）。以此引发ε-CBz（L-赖氨酸）-N-羧酸酐的开环聚合，得到阳离子三嵌段共聚物甲氧基聚乙二醇-b-聚己内酯-b-聚L-赖氨酸（mPEG-PCL-PLL）。该共聚物可在水中直接自组装成具有疏水核心和阳离子冠层的纳米级胶束。因此，它们可以进一步与阴离子siRNA复合，有望用于基因递送。

Amino-terminated methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL-NH2) was synthesized by azidizing the end OH group of mPEG-PCL and by subsequent hydrogenation of the azido group. It was used to initiate ring-opening polymerization of ε-CBz (L-lysine)-N-carboxyanhydride to obtain cationic triblock copolymer methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(L-lysine) (mPEG-PCL-PLL). The copolymer could self-assemble directly in water into nanoscale micelles with a hydrophobic core and a cationic corona. Therefore, they can further complex with anionic siRNA for possible application in gene delivery.

西安齐岳生物提供相关产品：

PLL-OPSS

Trt-PLL

FITC-PLL

PGA-Aldehyde

PGA-N3

PGA-SH

PGA-Biotin

PGA-NH2

PGA-ALK

PGA-OPSS

Trt-PGA

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